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Symbol
Name
ID

Tuba1a
tubulin, alpha 1A
MGI:98869

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes

Microcephaly

Aganglionic megacolon

Optic nerve hypoplasia

Spasticity

Spastic tetraplegia

Hypoplasia of the brainstem

Dilated fourth ventricle

Ventriculomegaly

Lissencephaly

Agyria

Pachygyria

Polymicrogyria

Perisylvian polymicrogyria

Dysgenesis of the basal ganglia

Dysplastic corpus callosum

Agenesis of corpus callosum

Partial agenesis of the corpus callosum

Hypoplasia of the corpus callosum

Hypoplastic anterior limbs of the internal capsule

Dysgenesis of the hippocampus

Hypoplastic hippocampus

Cerebellar vermis hypoplasia

Gray matter heterotopia

Periventricular laminar heterotopia

Ataxia

Intellectual disability, severe

Global developmental delay

Motor delay

Seizure

Bilateral tonic-clonic seizure

Focal-onset seizure

Generalized tonic seizure

Infantile spasms

Disease(s) Associated with TUBA1A

lissencephaly 3

Mouse Phenotypes

increased neuron apoptosis

abnormal neuronal migration

decreased neuronal precursor proliferation

increased neuronal precursor proliferation

abnormal telencephalon development

abnormal cortical intermediate zone morphology

abnormal cortical plate morphology

abnormal cortical ventricular zone morphology

enlarged lateral ventricles

enlarged third ventricle

abnormal third ventricle morphology

abnormal basal ganglion morphology

abnormal hippocampus morphology

abnormal Ammon gyrus morphology

abnormal dentate gyrus morphology

abnormal hippocampal mossy fiber morphology

abnormal hippocampus pyramidal cell layer

decreased hippocampus pyramidal cell number

abnormal cerebral cortex morphology

abnormal cerebral cortex pyramidal cell morphology

abnormal somatosensory cortex morphology

abnormal visual cortex morphology

abnormal auditory cortex morphology

abnormal neuron morphology

abnormal dendrite morphology

abnormal neuronal precursor cell number

abnormal neuron physiology

Availability

Mouse Genotype

Tuba1a^em1Rstot/Tuba1a^em1Rstot

Tuba1a^em2Rstot/Tuba1a^em2Rstot

Tuba1a^quas/Tuba1a^quas

Tuba1a^em1Rstot/Tuba1a^quas

Tuba1a^Jna/Tuba1a⁺

Tuba1a^Rgsc1736/Tuba1a⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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